![]() To achieve this, we exploited a previously reported DNA aptamer that recognizes phenylalanine in complex with a rhodium-based “receptor” that improves affinity. Thus motivated, we have adapted here the electrochemical aptamer-based sensing platform to the problem of rapidly and conveniently measuring the level of phenylalanine in the blood, an ability that would aid the monitoring and management of phenylketonuria (PKU). ![]() By analogy to the revolution the “home glucose monitor” created in the treatment of diabetes, the availability of a modular, “platform” technology able to measure nearly any metabolite, biomarker, or drug “at-home” in unprocessed, finger-prick volumes of whole blood could revolutionize the monitoring and treatment of disease.
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